Bioengineering Fermenters and
Bio Reactors
KLF Small Laboratory Fermenter
The in situ sterilizable Small Laboratory Fermenter KLF with total
volumes 2.4, 3.1 or 3.7 litres is especially suited for scale-up and
screening in research and education. Due to its modular design the
cultivation of bacteria, plant or animal cells is made possible with minimum
adaptations.
Laboratory Fermenter
L1523
The in situ sterilizable Laboratory Fermenter L1523 is available in steel or
glass in different sizes from 5.5 up to 19 litres fermentation volumes. A
range of stirring and aeration units are easily interchangeable to meet the
exact needs of your culture.
Laboratory Fermenter
NLF
The mobile Laboratory Fermenter NLF (total volumes from 16 to 30 litres)
can be easily integrated in a laboratory. Special features such as a double
jacketed vessel bottom for optimal temperature control and the double
mechanical seal with the removable stirrer shaft are standard equipment.
Laboratory Pilot
Fermenter LP351
The Laboratory Pilot Fermenter LP351 with total volumes 42, 50, or 75
litres - a multipurpose fermenter for scale up processes as well as for the
validated production of pharmaceuticals. The plant is equipped with a
sampling and bottom valve, autosterile filter, double mechanical seal and a
closed heating circuit.
Pilot Fermenters P
With their total volumes of 100 to 1000 litres the Pilot Fermenters P
are used in pilot processes, for production or as scale up steps in
large-scale production - from simple, manually operated reactor to fully
automated plant.
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Metabolic Engineering - Systems Biology
Metabolic engineering
is a new engineering and systems - oriented approach to the analysis
and synthesis of entire biological systems with the aim of
controlling cellular properties. Over and above systems analysis,
the design aspect related chiefly to the improvement of yield,
selectivity and productivity when biological systems are employed in
production processes, but can also be oriented to key medical
problems in the area of metabolic disorders. Holistic ideas about
the network character of cellular metabolism and the structuring of
the biological system in functional modules are keynote topics in
metabolic engineering.
The handling of these
ambitious questions must begin with comprehensive experimental and
theoretical studies of the complex reaction event in the interior of
the cell. Research in this field focuses on topological
investigations, analyses of flow distributions, and mathematical
modeling and simulation. These are supported by thorough
experimental studies under controlled and reproducible conditions in
bioreactors (capacities of these bioreactors range from 0.5 L to 300
L) and accompanied by a broad spectrum of modern bioanalyses. Work
deals with biological systems of various bacteria, yeasts and fungi
as well as mammalian cell cultures. Interesting applications of
these calculations, incorporated in a user-friendly modular software
package, include the estimation of theoretical yields and the
calculation of nutrient media composition.
Against the
background of measures to improve yield, selectivity and
productivity, the reaction steps and metabolic pathways that limit
the desired output must then be identified. Key tools here are
dynamic models of metabolic networks, which subsequently make it
possible to identify limiting steps through sensitivity analyses
(metabolic control analysis, MCA) or direct optimization methods.
The models used are based on an aggregation of enzyme-catalyzed
reactions in the metabolic network.
$ Ordering Information
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763-712-8717 / 800-745-2710 for more information.
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