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Microarrays are not limited to DNA analysis; protein microarrays, antibody microarray, Chemical Compound Microarray can also be produced using biochips. Randox Laboratories Ltd. launched Evidence®, the first protein Biochip Array Technology analyzer in 2003. In protein Biochip Array Technology, the biochip replaces the ELISA plate or cuvette as the reaction platform. The biochip is used to simultaneously analyze a panel of related tests in a single sample, producing a patient profile. The patient profile can be used in disease screening, diagnosis, monitoring disease progression or monitoring treatment. Performing multiple analyses simultaneously, described as multiplexing, allows a significant reduction in processing time and the amount of patient sample required. Biochip Array Technology is a novel application of a familiar methodology, using sandwich, competitive and antibody-capture immunoassays. The difference from conventional immunoassays is that the capture ligands are covalently attached to the surface of the biochip in an ordered array rather than in solution.

In sandwich assays an enzyme-labelled antibody is used; in competitive assays an enzyme-labelled antigen is used. On antibody-antigen binding a chemiluminescence reaction produces light. Detection is by a charge-coupled device (CCD) camera. The CCD camera is a sensitive and high-resolution sensor able to accurately detect and quantify very low levels of light. The test regions are located using a grid pattern then the chemiluminescence signals are analysed by imaging software to rapidly and simultaneously quantify the individual analytes.

Biochip and biosensor technology development today secures the new advanced level of medicine and pharmacology of tomorrow. Introduction of new precise and early diagnostic techniques, turning upside down the current understanding of untreatable diseases, complex application of the novel methods of diagnoses and localization, drug delivery techniques and treatment control will be at a large extent based on success in development, fabrication and implementation of novel materials and technologies towards creating state-of-the-art biochips and biosensors.

Need 'conviction' in your laboratory?....then go for the Evidence!

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