Agilent 1100 LC MSD Model G1946D Mass Spectrometer

Agilent 1100 LC MSD Model G1946D Mass Spectrometer

  • Agilent 1100 LC/MSD Model G1946D
  • ElectroSpray ionization Source
  • Mass Range 2-3000 amu
  • LAN Communications
  • Roughing Pump
  • Complete Data system

To help you make a wiser decision in choosing a specific HPLC System, follow our HPLC System Purchasing Guide, Get Your FREE Used HPLC Purchasing Guide Here.


For more information or to place an offline order call 1-800-745-2710


We Accept Trade-ins!

Don’t forget to tell us about any unused

instruments taking up space in your lab.


Agilent 1100 LC/MSD with Model G1946D mass spectrometer.
Agilent 1100 G1956D LC MS  refurbished to specifications, ESI source, roughing pump, complete data system.  *Professional installation available.

In 1997 HP introduces its first benchtop quadrupole LC/MS the 1100 Series LC/MSD. The 1100 Series LC/MSD provides information quickly in one chromatographic run. It provides molecular weight structural information and has excellent selectivity needed to identify compounds check the purity of chromatographic peaks and quantitate trace level samples in complex matrices in a rugged reliable easy-to-use benchtop system. For chromatographers and mass spectrometrists who need the utmost in sensitivity the LC/MSD SL makes analyses in the very low picogram range possible*

The 1100 Series LC/MSD offers many advantages as an LC detector. It offers the dynamic range and repeatability needed for most quantitative applications. In the SIM mode it offers high sensitivity. For compounds lacking a strong chromophore it offers detection limits not possible with other detectors. By offering unit mass resolution to m/z 3000 the LC/MSD allows for characterization of large proteins beyond 60000 KDalton. Having extended mass range to 3000 is also beneficial when studying modified proteins such as glycoproteins where their charge distribution falls above m/z 2000.

The Agilent 1100 Series LC/MSD is a benchtop mass spectrometer designed to be integrated with the 1100 Series HPLC System. It is a quadrupole based atmospheric pressure ionization (API) instrument capable of doing both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). The LC/MSD can handle normal HPLC flow rates (1 ml/min) without splitting the effluent and with minimal adjustment of the spray chamber.

Optional Configuration

  • Agilent/HP 1100 Series G1312A Binary Pump
  • Agilent/HP 1100 Series G1313 Autosampler
  • Agilent/HP 1100 Series G1316A Column compartment
  • Agilent/HP 1100 Series G1322A Degasser and Solvent tray
  • More Configurations available


Mass spectrometry plays an important role in the entire life cycle of a drug from discovery to development to manufacturing. In drug discovery LC/MS systems are the method of choice for identifying and characterizing of drug candidates produced by combinatorial chemistry or extracted from natural products. They are also a primary tool used to check drug compound quality during manufacturing.


Proteomics is the large-scale analysis of proteins for disease research and drug discovery. MS analysis is a fundamental tool for proteomic research. In addition to LC/MS instruments for identifying and quantifying proteins in biological samples Agilent has developed wide range of complementary technologies to help researchers prepare separate analyze identify and interpret challenging protein samples.


This rapidly growing area of life science research is the study of small molecules known as "metabolites" which are products of metabolism in tissues. The makeup of these sets of molecules is increasingly being associated with a number of illnesses. GC/MS and LC/MS are the main analytical techniques to detect and measure large numbers of metabolites. Agilent also offers the METLIN personal metabolite database to help users identify the metabolites they find and profiling software to compare large sets of metabolite data to one another.


The ability to identify and quantify pollutants is essential to maintaining a health environment. A mainstay of environmental testing GC/MS is used to detect volatile organic compounds such as pesticides. Agilent is the worldwide leader in GC/MS. Inductively coupled plasma mass spectrometry (ICP-MS) helps identify and quantify inorganic compounds and heavy metals. LC/MS is a popular complement to GC/MS; it can analyze more fragile chemicals that may not stand up well to GC/MS analysis.

Food safety:

GC/MS LC/MS and ICP-MS are widely employed for food safety testing which includes the analysis of additives residues contaminates and toxins in agricultural products and foods. The need for food testing is growing rapidly driven by the liberalization of global trade a more stringent regulatory environment and increased public awareness of food safety issues.


Mass spectrometry has long been a mainstay in applications that involve the analysis of small thermally stable organic compounds inorganic compounds and metals. More recently the development of new technology has dramatically increased the ability of mass spectrometers to analyze large relatively fragile biological molecules such as proteins opening vast new applications for MS. Important applications and markets for MS include:


Agilent is the worldwide leading provider of GC/MS systems for drug screening and toxicology. As with the environmental industry Agilent LC/MS systems are beginning to be employed for forensic analyses as a complement to GC/MS. ICP-MS coupled to laser ablation (LA-ICP-MS) is also useful for measuring solid samples as well as for elemental fingerprinting of materials in forensic investigations

Hydrocarbon Processing Industries (HPI)

HPI comprises the petroleum petrochemical fine and specialty chemical natural gas industrial gas and fuel cell industries. Agilent mass spectrometers particularly GC/MS systems are routinely used process performance in QA/QC and process control.


Agilent 1100 LC MSD Model G1946D Mass Spectrometer Specifications

Mass Range2-3000 amu
Mass Accuracy+/- 0.13 u within the calibrated mass range in scan mode
Mass Axis Stability+/- 0.13 u over 8 hours
Scan Speed2500 u/s standard mode
5250 u/s fast scan mode
SIM SensitivityESI at 400 ul/min
APCI at 1000 ul/min
Selected ion monitoring of m/z 609.3
Positive ionization
Signal To Noise Ratio
Quantity: 1 pg reserpine 100:1 RMS (20:1 peak-to-peak)
Scan SensitivityESI at 400 ul/min
APCI at 1000 ul/min
Scan range m/z 100-650
Scan speed 2500 u/s
Extracted ion at m/z 609.3
Positive ionization
Signal To Noise Ratio
Quantity: 50 pg reserpine 100:1 RMS (20:1 peak-to-peak)
Multiple Signal AcquisitionAbility to cycle
GMI Certified Service means:
  • Healthy operation of your instrument
  • Helping to ensure the quality of your results
  • Lowering cost of ownership through multilple service agreement options
  • Prolonging instrument serviceable life
  • Safe Operation of your equipment
  • Minimizing downtime increases productivity and minimizes revenue loss
  • Instrument Evaluation Services
  • Contract Refurbishing
  • Relocation Services
  • Equipment Finder Service
  • Training Courses
  • Depot Repair
  • Instrument Decommisioning & Disposal Services
Service Agreements

Preventative Maintenance Visit
('tune up', including cleaning, lubrication, and adjustments)
1 Service Visit
Service Visit 1PM
1 Service Visit
1 2
Parts and Labor    

Discounted Parts
Discounted Labor (As needed)

Lab Equipment Replacement Parts & Accessories

Click button to view parts which are available for this instruments and instruments like it in our brand new online parts shop.

We also carry instruments parts for the following other instruments categories.


Your trusted source for new, factory clearance & certified pre-owned lab instruments since 1995.

  • We routinely save discerning laboratories 30-80% with our recertified pre-owned and factory clearance instrument offerings.

  • Quality? ISO 9001:2008 certified means we remove 100% of the risk in buying ‘used’ laboratory equipment.

  • Warranties from 90 days to a year as well as multi-year service agreements are available.

GMI is an ISO 9001:2008 certified company - proof that your instruments pass through a rigorous re-certification process to ensure that it arrives at your laboratory defect-free and in full working order.
We are neither an auction company nor an instrumentation broker. GMI employs our own factory-trained engineers to ensure full control of this process.
Unlike small-time businesses and brokers, GMI goes beyond offering money-back promises. We offer real product warranties.
Apart from our meticulous inspection processes, GMI’s available warranties and multi-year service agreements guarantee customer satisfaction - no need to go through frustrating and time-consuming product returns!
Additionally, all items are thoroughly cleaned and professionally packaged/crated with care to insure they arrive in your lab ready for use.