Agilent 1100 LC MSD Model G1946D Mass Spectrometer

Specifications

Pharmaceutical

Mass spectrometry plays an important role in the entire life cycle of a drug from discovery to development to manufacturing. In drug discovery LC/MS systems are the method of choice for identifying and characterizing of drug candidates produced by combinatorial chemistry or extracted from natural products. They are also a primary tool used to check drug compound quality during manufacturing.

Proteomics

Proteomics is the large-scale analysis of proteins for disease research and drug discovery. MS analysis is a fundamental tool for proteomic research. In addition to LC/MS instruments for identifying and quantifying proteins in biological samples Agilent has developed wide range of complementary technologies to help researchers prepare separate analyze identify and interpret challenging protein samples.

Metabolomics

This rapidly growing area of life science research is the study of small molecules known as “metabolites” which are products of metabolism in tissues. The makeup of these sets of molecules is increasingly being associated with a number of illnesses. GC/MS and LC/MS are the main analytical techniques to detect and measure large numbers of metabolites. Agilent also offers the METLIN personal metabolite database to help users identify the metabolites they find and profiling software to compare large sets of metabolite data to one another.

Environmental

The ability to identify and quantify pollutants is essential to maintaining a health environment. A mainstay of environmental testing GC/MS is used to detect volatile organic compounds such as pesticides. Agilent is the worldwide leader in GC/MS. Inductively coupled plasma mass spectrometry (ICP-MS) helps identify and quantify inorganic compounds and heavy metals. LC/MS is a popular complement to GC/MS; it can analyze more fragile chemicals that may not stand up well to GC/MS analysis.

Food safety

GC/MS LC/MS and ICP-MS are widely employed for food safety testing which includes the analysis of additives residues contaminates and toxins in agricultural products and foods. The need for food testing is growing rapidly driven by the liberalization of global trade a more stringent regulatory environment and increased public awareness of food safety issues.

Applications

Mass spectrometry has long been a mainstay in applications that involve the analysis of small thermally stable organic compounds inorganic compounds and metals. More recently the development of new technology has dramatically increased the ability of mass spectrometers to analyze large relatively fragile biological molecules such as proteins opening vast new applications for MS. Important applications and markets for MS include:

Forensics

Agilent is the worldwide leading provider of GC/MS systems for drug screening and toxicology. As with the environmental industry Agilent LC/MS systems are beginning to be employed for forensic analyses as a complement to GC/MS. ICP-MS coupled to laser ablation (LA-ICP-MS) is also useful for measuring solid samples as well as for elemental fingerprinting of materials in forensic investigations

Hydrocarbon Processing Industries (HPI)

HPI comprises the petroleum petrochemical fine and specialty chemical natural gas industrial gas and fuel cell industries. Agilent mass spectrometers particularly GC/MS systems are routinely used process performance in QA/QC and process control.