Randox EVIDENCE Investigator Biochip Array Technology

Randox EVIDENCE Investigator Biochip Array Technology

  • One system for protein and DNA chips
  • Detection of DNA polymorphisms and mutations
  • Multiplexing: one sample multiple results
  • Biochips are ready-to-use
  • Multiple arrays of tests and multiple tests per sample


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The Randox Evidence Investigator is the ultimate research and clinical biochip reader: dedicated to multi-analysis utilizing the full Randox portfolio of biochip assays. The Evidence Investigator is a compact bench-top biochip system comprising a super cooled charge couple device (CCD) camera and unique image processing software. The Evidence Investigator extends itself to the full range of both human and animal clinical research

The Randox Evidence Investigator offers a wide-ranging test and 'in development' menu for protein and DNA biochips. The state of the art technology employed by the evidence investigator is both user friendly and offers a respectable throughout.

The Randox Evidence Investigator system is based on the use of a biochip as a platform for immunoassay measurement. Conventional immunoassay techniques are utilised for the measurement of analytes on the surface of a biochip which results in the specific and simultaneous profiling of markers. Rather than having to divide and separately test a patient sample to obtain each test result evidence investigator offers a means for simultaneous testing of a sample and thus provides a more complete diagnostic profile for each patient. The Cytokine and Growth Factors array measures 12 analytes from a single sample.

All reagents required to run assays are provided in a single kit ? assay buffer multi-analyte conjugate nine levels of multi-analyte calibrator wash buffer and signal reagent. Multi-analyte controls are available as a separate kit. The evidence investigator CVs are below 10% thus providing the user with confidence in results obtained. There is reduced variation as all results are determined at the exact same time point. One vial of multi-analyte calibrator is all that is required for each of the nine levels. An extensive QC menu including Levey Jennings charts with multi-point rules and multi-analyte QC material is available for all arrays.

The evidence investigator test menus are arranged into disease orientated test arrays or by group association

The Randox Biochip
The Evidence Investigator utilizes a biochip as a reaction platform. The biochip is a 9mm2 solid substrate with multiple specific ligands (antibodies or antigens) attached at pre-defined sites on the surface. At present up to 100 tests can be pre-fabricated onto the biochip surface. In the future the capacity of tests per biochip can be increased dramatically.

Randox Methodology
The evidence investigator utilizes the basic principles of immunology; supporting competitive sandwich and antibody capture immunoassay formats. The competitive assay utilizes an enzyme labeled analyte for signal production whereas the sandwich assay utilizes an enzyme labeled antibody. The chemiluminescence signals are simultaneously measured for the full array of tests on each chip.

Randox Evidence Investigator Features

  • One system for protein and DNA chips
  • Detection of DNA polymorphisms and mutations !
  • Multiplexing: one sample multiple results
  • Biochips are ready-to-use
  • Multiple arrays of tests and multiple tests per sample
  • Minimal sample volume 25-100u per array
  • Multi-analyte calibrators controls and reagents
  • Only 2 assay reagents per panel
  • Bar-coded calibrators
  • Platform ideal for additional proteomics
  • Clinical control with calibrated methods and quality control materials
  • DNA-based biochips
  • Customized biochips available

Randox Evidence Investigator ARRAYS

Cardiac array

Cardiac biomarkers are enzymes proteins and hormones that are associated with heart function damage or failure. Some of the tests are specific for the heart while others are also elevated with skeletal muscle damage. Cardiac biomarkers are used for diagnostic and prognostic purposes and are frequently ordered by doctors when someone comes into A&E complaining of symptoms such as chest pain pressure nausea and shortness of breath.

The cardiac array of tests are presented on a single biochip. All six tests are performed simultaneously using just one assay diluent one panel-specific conjugate solution and one signal reagent.

Cardiac array test menu

  • Troponin I
  • Myglobin
  • CK-MB
  • Carbonic Anhydrase III (CA III)
  • Glycogen Phosphorylase BB (GPBB)
  • Fatty Acid Binding Protein (FABP)

The cardiac biochip measures 6 cardiac biomarkers from one patient sample revealing a great deal more information than a single test this is the power of biochip array technology.

Cytokines & growth factors array

Cytokines and growth factors are proteins secreted primarily by immune system cells such as leucocytes. They are a means of intercellular communication with both immune and non-immune system cells. Upon binding to a cell membrane receptor cytokines initiate a signal transduction cascade in their target cell. Cytokines form a complex web of interactions since:

  • Different cytokines can have similar effects.
  • Cells interact with a variety of cytokines.
  • Cytokines may affect the activity and expression of other cytokines.

Cytokines and growth factors array test menu

  • Interleukin-1 alpha (IL-1a)
  • Interleukin-1 beta (IL-1b)
  • Interleukin-2 (IL-2)
  • Interleukin-4 (IL-4)
  • Interleukin-6 (IL-6)
  • Interleukin-8 (IL-8)
  • Interleukin-10 (IL-10)
  • Interleukin-12 (IL-12) - in development
  • Vascular Endothelial Growth Factor (VEGF)
  • Tumour Necrosis Factor-alpha (TNF-a)
  • Interferon-gamma (IFN-g)
  • Epidermal Growth Factor (EGF)
  • Monocyte Chemotactic Protein-1 (MCP-1)

Adhesion molecules array

The adhesion molecules array of tests are presented on a single biochip. All five tests are performed simultaneously using just one assay diluent one panel-specific conjugate solution and one signal reagent. The following adhesion molecule markers are measured on one biochip:

  • ICAM-I
  • VCAM-I
  • E - selectin
  • P - selectin
  • L - selectin

Drugs of abuse array I

  • Amphetamine
  • Methamphetamine
  • Cocaine
  • Barbiturates
  • Cannabinoids
  • Opiates
  • Methadone
  • Benzodiazepines
  • Lorazepam
  • Phencyclidine
  • Creatinine

Free thyroid array

  • Thyroid stimulating hormone (TSH)
  • Free tri-iodothyronine (FT3)
  • Free thyroxine (FT4)

Total thyroid array

  • Thyroid stimulating hormone (TSH)
  • Total tri-iodothyronine (TT3)
  • Total thyroxine (TT4)

Fertility array

  • Follicle stimulating hormone (FSH)
  • Prolactin (PRL)
  • Lutenising Hormone (LH)
  • Estradiol*
  • Progesterone
  • Testosterone

Tumor monitoring array

  • Carcinoembryonic antigen (CEA)
  • a- Fetoprotein (AFP)
  • Human chorionic gonadotrophin (hCG)
  • Gastrointestinal tumour antigen (CA 19-9)
  • Ovarian Tumour antigen (CA 125)
  • Breast cancer antigen (CA 15-3)

Tumor PSA array

  • Total prostate specific antigen (tPSA)
  • Free prostate specific antigen (fPSA)
  • Carcinoembryonic antigen (CEA)

Cardiac array

  • Troponin I
  • Myoglobin
  • CK-MB
  • Carbonic Anhydrase III (CA III)
  • Glycogen Phosphorylase BB (GPBB)
  • Fatty Acid Binding Protein (FABP)

Multi-analyte quality controls

  • Drugs of Abuse
  • Cardiac
  • Cytokine
  • Immunoassay
  • Customised quality controls


growth promoter array I

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